Proof of concept of gene editing in human germline

In the recent post titled “1975, The Asilomar Conference. 2015, Asilomar 2.0?“, I referenced the call published on March 3rd in Science by renowned scientist for a  “A prudent path forward for genomic engineering and germline gene modification“. Nature also published a similar call on March 12 “Don’t edit the human germ line”.

It appears that Sciences and Nature have rejected the submission of an article that eventually has been published in Protein & Cell. In this paper, Chinese researchers of Guangzhou (Canton) University demonstrate the successful targeted gene sequence modification in 4 embryo out of 86 injected with a specifically engineered CRISPR/Cas9 complex.

The experiment is only a proof of concept, with several remaining issues: low yield, false positive, collateral mutations. But research will continue and the problems will be solved.

So, you may be OK to eat GMO food. But are you OK with GMO babies?


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